University of Heidelberg


19.05.15 00:00 Age: 6 yrs

Slow Science - Prof. Jeremy Gunawardena - Wednesday, May 27, 2015 - 3:00 p.m.


On behalf of Roland Eils, we kindly invite you to a talk by Jeremy Gunawardena, Associate Professor for Systems Biology at Harvard Medical School’s Systems Biology Department. Entitled “How can eukaryotic genes switch on sharply?“ (see attached abstract) Prof. Gunawardena’s talk will take place on Wednesday, May 27, 2015 at 3:00 p.m. in Lecture Hall SR041 in the BioQuant building (INF 267).

This talk will kick of a new series called Slow Science. This is a format dedicated to the presentation of current issues in modern life sciences across disciplines. The only rule we have is: no slide shows. The Slow Science talks will be held using only a black/white board for illustration purposes. Some of you might be familiar with these chalk talks from other institutions or seminars. The aim is to focus visualization only on the most important aspects of the talk and encourage interaction with the audience.

The series is hosted by the BioQuant board of directors and is kindly supported by CellNetworks.

Abstract: I will discuss some new developments for mathematically analysing eukaryotic genes, which allow for higher-order cooperative interactions between multiple regulators as well as the effects of energy dissipation, and will show how these mechanisms appear to be necessary to account for experimental data on the sharpness with which genes are switched on during early development. In particular, I will explain how, in the absence of energy dissipation, sharpness is limited by a "Hopfield barrier" that is defined by the much used but little understood Hill function.

Contact: E-Mail (Last update: 28/11/2011)