University of Heidelberg


Oct. 6-7, 2017: 3rd Workshop on Virus Dynamics

Oct. 9-10, 2017: Hengstberger-Symposium on Systems Immunology & Vaccine Design


Why does our immune system work the way it works? How does it actually work? And what is the reason that our immune system fails to work sufficiently against some types of infectious pathogens?

In our group, we are combining mathematical models and experimental data to understand fundamental immunological and virological processes that occur within a host in response to infection. We are particularly interested in the spatio-temporal dynamics of infection and immune processes, and how these dynamics determine the outcome of an infection or the efficacy of therapeutic interventions. Thereby, we especially aim at determining how single-cell behaviour shapes cell population dynamics. To this end, we develop mathematical methods and computational tools to analyse and understand how pathogens spread within different tissue environments, and how our immune system is able to memorize previous infections. 

Below you find an enumeration of specific topics and projects that we are currently working on in close collaboration with several experimental groups. These projects address open questions on specific aspects of host-pathogen interactions of different pathogens (such as HIV, HCV, Malaria and Ebola) and on the generation of immunological memory.


(1.) Viral spread in complex environments

(2.) CD8+ T cell differentiation and migration

(3.) Malaria pathogenesis and vaccination approaches

Contact: E-Mail (Last update: 11/06/2018)