University of Heidelberg
BIOQUANT

Teaching News

SS2017

Biophysics of Sensing and Signaling
Start: Monday April 24th @2pm, SR43

Seminar: Biophyiscs of Sensing and Signaling

Content

Cells have remarkable abilities to respond to changes in their environment. This seminar focuses on signal reception and processing in cells from a biophysical perspective. With the help of common biological model systems we will analyze qualitatively and quantitatively how cells sense and respond to their chemical, social and physical environment, discussing phenomena such as chemotaxis, quorum sensing control or mechano-sensing. We will elucidate the biophysical limitations of cellular information processing in each case and introduce key concepts that have enabled cells to successfully combat these challenges. With the help of generic biophysical models we will address: 1) how signals are sensed by allosteric receptors, 2) how information is processed by cellular signal transduction networks to extract biologically relevant information from such signals (bio-computing) and 3) how cells achieve specific and robust information transfer. We will apply these concepts to the different biological model systems using relevant data from the literature. The ultimate goal of the seminar is to provide students with the knowledge that should enable them to 1) make informed comparisons between different sensory systems, 2) to use biophysical insight for hypothesizing about common principles and system-specific “design solutions” that have evolved in nature and 3) to apply this knowledge for biotechnological applications in order to interfere with signaling or to rationally (re)engineer a sensory network.

 

Required Background

This seminar is targeted at advanced biology, biotechnology and physics students with an interest in interdisciplinary approaches. For the biology and biotechnology students, some mathematical knowledge on kinetic equations is helpful, but not required. For the physics students, some knowledge in statistical physics and biophysics is helpful, but not required. The seminar aims to build the foundation for fruitful and efficient interdisciplinary research of the participants. In order to take advantage from the expertise of the other field, students must learn how to effectively communicate with each other by developing a common terminology and appreciate the competencies of the other field. Three supervisors with expertise in theoretical (bio)physics, biomechanics and quantitative microbiology will aid into this task and guide the students through the semester by taking advantage of different scientific presentation modes (short talks, seminar talks, poster presentation) that should facilitate fruitful exchange among students with different scientific backgrounds.

 

Organization

This seminar is jointly organized by Nils Becker (DKFZ and Bioquant), Ilka Bischofs (MPI Marburg and Bioquant) and Ulrich Schwarz (Department of Physics and Bioquant). It will take place every Monday from 2.15 - 3.45 pm in seminar room 44 in the Bioquant building, INF 267. We will meet for the first time on Monday April 24th to discuss the details of the course. If the date Monday afternoon is a problem for several participants, we might consider running this at another date or as a compact course. If you want to pre-register, send an email to Ulrich Schwarz schwarz@thphys.uni-heidelberg.de (Physics) or Ilka Bischofs (ilka.bischofs@bioquant.uni-heidelberg.de) (Biology and Biotechnology).

 

Assessment of Student Performance

Biology and biotechnology students are encouraged to focus on a sensory model system of their choice. They will give short oral presentations throughout the semester and present a poster (2 CPs). Physics students are encouraged to focus on a physical key concept and will give a seminar talk and prepare a poster (PSEM 2CPs). Physics students in the Master program can earn 6 CPs (MVSem) by preparing in addition to the oral and poster presentation a written paper.

 

 

 

 

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Contact: E-Mail (Last update: 11/04/2017)