University of Heidelberg
BIOQUANT

Research Groups hosted in-house

Bischofs Lab: Complex Adaptive Traits (CAT)

Dr. Ilka Bischofs-Pfeifer

Our goal is to understand, to control and to engineer CATs using tools from molecular biology, microscopy and mathematical modelling.

Chlanda Lab: Membrane Biology of Viral Infection

Dr. Petr Chlanda

We are studying how viruses interact with cellular membranes and lipids during infection.

 

Erfle Lab: High-content Analysis of the Cell (HiCell)

Dr. Holger Erfle

The main focus is together with the research team »Integrin trafficking, microenvironment and ncRNAs« (Dr. Vytaute Starkuviene) the design, development and application of novel technologies for high-content screening and analysis.

 

Grabe Lab: Tissue Imaging and Analysis (TIGA) Center

Prof. Niels Grabe

We are dedicated to the quantitative analysis and modeling of tissues. A strong emphasis is placed on clinically relevant research projects.

 

Graw Lab: Modelling Infection and Immunity

Dr. Frederik Graw

We investigate infection and immune processes within a host by combining mathematical models and experimental data.

 

Grimm Lab: Virus-Host Interactions

Prof. Dirk Grimm

We work on gene therapy with non-pathogenic Adeno-associated viruses (AAV) - the most promising and most versatile viral vector for therapeutic gene transfer - which we engineer using a large portfolio of technologies and targeting a variety of diseases.

 

Biomedical Genomics Group - Health Data Science Unit

Dr. Carl Herrmann

We are working on understanding gene (de)regulation in disease and develop novel methods to integrate large scale genomics datasets, using statistical and machine-learning approaches. We focus in particular on epigenomics data and single-cell approaches.

 

Modeling of Biological Processes

Prof. Ursula Kummer

We develop methods for the simulation, modelling and analysis of biochemical networks and apply these methods to tackle specific biochemical questions.

 

Single-cell Open Lab (scOpenLab)

Dr. Jan-Philipp Mallm

We focus on providing automated, high-throughput and multi-omic readouts tailored to cancer research.

 

Molnár-Gabor Group

Dr. jur. Fruzsina Molnár-Gabor

Niopek Lab: Synthetic Biology

Dr. Dominik Niopek

How can we precisely perturb and control molecular processes in living eukaryotic cells? Our lab approaches this question from a synthetic biology and protein engineering perspective. We juxtapose various methods, namely optogenetics, CRISPR, viral vectors and computation and develop molecular tools to study genome regulation and direct cell function.

 

Pahle Lab: Biological Information Processing

Dr. Jürgen Pahle

We analyse how living systems take up, process, store and transfer information.

 

Chromatin Networks

Prof. Karsten Rippe

We combine molecular/cell biology and physics to develop quantitative descriptions that relate the dynamic organization of the (epi)genome with gene expression programs and functional cell states.

 

Biomedical Computer Vision Group

PD Dr. Karl Rohr

We develop methods and algorithms for computer-based analysis of biological and medical images, in particular, cell microscopy images and medical tomographic images.

 

Russell Group: Protein Evolution

Prof. Rob Russell

We are interested in all aspects of protein structure, function and evolution. We mostly focus on studies of molecular interactions: protein-protein, protein-peptide, protein-chemical, etc.

 

Saez-Rodriguez Group: Systems Biomedicine

Prof. Julio Saez-Rodriguez

We study the deregulation of signaling networks to develop novel therapeutics for cancer, autoimmune and fibrotic diseases by integrating multi-omics data and biological knowledge into mathematical models.

 

Sahle Group: Methods in Computational Systems Biology

Dr. Sven Sahle

We develop computational methods for modeling and analyzing biochemical reaction networks, using different mathematical frameworks like ODEs, PDEs or stochastic processes. As a service for the community we also develop and provide software for general use in systems biology.

 

Schröder Group: Cryo-Electron Microscopy

Prof. Rasmus Schröder

We cooperate with various Heidelberg groups within the CryoEMNetwork, including research projects in the field of single particle analysis and electron cryo tomography on protein suspensions and cryosections of cellular samples. Our own biomedical focus is on the actin-myosin macromolecular motor system.

 

Research Groups with projects in-house

Boutros Lab: Signaling Networks / ERC DECODE

Prof. Michael Boutros

We use genetic and genomic approaches to study cellular signaling networks, with a particular focus on Wnt and Wnt-interacting pathway.

 

Halama Lab: Translational Immunotherapy

PD Dr. Niels Halama

Our group is focusing on immunotherapy of solid tumor. The main interest is in tissue processing workflows and technologies using whole slide image processing/quantification coupled with multiplex protein quantification to address basic scientific questions. These workflows and technologies are being applied in translational projects with implementation in clinical trials.

 

Health Data Science Unit

Prof. Roland Eils

We are working on novel, interoperable solutions in medical informatics with the aim to make medical patient data accessible for clinical research and education which will, in turn, improve patient care.

 

Heilemann Lab: Single Molecule Biophysics

Prof. Mike Heilemann

We study the structural organization of biomolecules in cells applying novel microscopic techniques that provide single-molecule sensitivity and a spatial resolution below the diffraction limit.

 

Huber Group / ERC DECODE

Dr. Wolfgang Huber

Systems Biology of Signal Transduction

Prof. Ursula Klingmüller

Our goal is to gain insights into molecular mechanisms that regulate cellular decisions and to address their impact on behavior at the tissue- and organ-level.

 

Kräusslich Lab: Retroviral and Influenza Virus (IAV) Biology

Prof. Hans-Georg Kräusslich

 

Lohmann Lab / ERC DECODE

Prof. Jan Lohmann

 

Applied Analysis and Modelling in Biosciences

Prof. Anna Marciniak-Czochra

The group is focused on multi-scale mathematical modelling and analysis of the dynamics of structure formation and self-organisation in cell systems.

 

Schwarz Group: Physics of Complex Biosystems

Prof. Ulrich Schwarz

In our work, we aim at developing a systems level understanding of cell mechanics and adhesion.

 

Stegle Group / ERC DECODE

Dr. Oliver Stegle

Wittbrodt Group: ERC INDIGENE

Prof. Jochen Wittbrodt

Contact: E-Mail (Last update: 18/12/2020)