University of Heidelberg
BIOQUANT

Publications

2023

  • Ince LM, Barnoud C, Lutes LK, Pick R, Wang C, Sinturel F, Chen CS, de Juan A, Weber J, Holtkamp SJ, Hergenhan SM, Geddes-McAlister J, Ebner S, Fontannaz P, Meyer B, Vono M, Jemelin S, Dibner C, Siegrist CA, Meissner F, Graw F, Scheiermann C: Influence of circadian clocks on adaptive immunity and vaccination responses. Nat. Comm. 2023, 14(1):476. doi: 10.1038/s41467-023-35979-2

2022

  • Heuss C, Rothhaar P, Burm R, Lee JY, Ralfs P, Haselmann U, Ströh LJ, Colasanti O, Tran CS, Schäfer N, Schnitzler P, Merle U, Bartenschlager R, Patel AH, Graw F, Krey T, Laketa V, Meuleman P, Lohmann V: A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo. PLoS Pathogens 2022, doi: https://doi.org/10.1371/journal.ppat.1010472
  • Harmel C, Sid Ahmed S, Koch R, Tünnermann J, Distler T, Imle A, Giorgetti L, Bahn E, Fackler OT, Graw F: VisuStatR - Visualizing motility and morphology statistics on images in R. Bioinformatics 2022, doi:10.1093/bioinformatics/btac191
  • Stolp B, Stern M, Ambiel I, Hofmann K, Morath K, Gallucci L, Cortese M, Bartenschlager R, Ruggieri A, Graw F, Rudelius M, Keppler OT, Fackler OT: SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models. Cell Reports 2022 doi:https://doi.org/10.1016/j.celrep.2022.110387

2021

  • Radev ST, Graw F, Chen S, Mutters NT, Eichel VM, Bärnighausen T, Köthe U: OutbreakFlow: Model-based Bayesian inference of disease outbreak dynamics with invertible neural networks and its application to the COVID-19 pandemics in Germany. PLoS Comp. Biol. 2021, 17(10):e1009472
  • Graw F: Deciphering the triad of infection, immunity and pathology. eLife 2021, 10:e72379, doi:10.7554/eLife.72379
  • Durso-Cain K, Kumberger P, Schälte Y, Fink T, Dahari H, Hasenauer J, Uprichard S, Graw F: HCV spread kinetics reveal varying contributions of transmission modes to infection dynamics. Viruses 2021, 13(7), doi:10.3390/13071308

2020

  • Ahmed SS, Bundgaard N, Graw F, Fackler OT: Environmental Restrictions: A New Concept Governing HIV-1 Spread Emerging from Integrated Experimental-Computational Analysis of Tissue-Like 3D Cultures. Cells 2020, 9, 1112; doi:10.3390/cells9051112
  • Madelain V, Mentré F, Baize S, Anglaret X, Laouénan C, Oestereich L, Nguyen THT, Malvy D, Piorkowski G, Graw F, Günther S, Raoul H, de Lamballerie X, Guedj J; Reaction! research group: Modeling favipiravir antiviral efficacy against emerging viruses: from animal studies to clinical trials. CPT Pharmacometrics Syst Pharmacol. 2020, doi: 10.1002/psp4.12510
  • Bretana NA, Gray RR, Cunnigham EB, Betz-Stablein B, Ribeiro RM, Graw F, Luciani F, Lloyd AR: Combined treatment and prevention strategies for hepatitis C virus elimination in the prisons in New South Wales: a modelling study. Addiction 2020, 115:901-913, doi: 10.1111/add.14830

2019

  • Gabel M, Hohl T, Imle A, Fackler OT, Graw F: FAMoS: A flexible and dynamic algorithm for model selection to analyze complex systems dynamics. PLoS Comp. Biol. 2019, 15(8):e1007230
  • Gabel M, Baumann NS, Oxenius A, Graw F: Investigating the dynamics of MCMV-specific CD8+ T cell responses in individual hosts. Front. Immunol. 2019, 10:1358. doi:10.3389/fimmu.2019.01358
  • Imle A, Kumberger P, Schnellbächer ND, Fehr J, Carrillo-Bustamante P, Ales J, Schmidt P, Ritter C, Godinez WJ, Müller B, Rohr K, Hamprecht FA, Schwarz US, Graw F, Fackler OT: Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures. Nat. Comm. 2019, 10:2144 (press release)
  • Piontek, T, Harmel C, Pawlita M, Carow K, Schröter J, Runnebaum IB, Dürst M, Graw F, Waterboer T: Post-treatment HPV antibody kinetics in cervical cancer patients. Phil. Trans. B 2019, 374: 20180295
  • Gambato M, Canini L, Lens S, Graw F, Perpiñan E, Londoño MC, Uprichard SL, Mariño Z, Reverter E, Bartres C, González P, Pla A, Costa J, Burra P, Cotler SJ, Forns X, Dahari H: Early HCV viral kinetics under DAAs may optimize duration of therapy in patients with compensated cirrhosis. Liver Int. 2019, 39:826-834 doi: 10.1111/liv.14014

2018

  • Frank R, Gabel M, Heiss K, Mueller AK, Graw F: Varying immunizations with Plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics. Front Immunol 2018, 9:1137. doi: 10.3389/fimmu.2018.01137
  • Kumberger P, Durso-Cain K, Uprichard SL, Dahari H, Graw F: Accounting for space - Quantification of cell-to-cell transmission kinetics using virus dynamics models. Viruses 2018, 10(4). pii E200. doi:10.3390/v10040200
  • Thakre N*, Fernandes P*, Mueller AK, Graw F: Examining the reticulocyte preference of two Plasmodium berghei strains during blood-stage malaria infection. Front Microbiol 2018, 9:166. doi: 10.3389/fmicb.2018.00166 (*these authors contributed equally)

2017

  • Gabel M, Regoes RR, Graw F: More or less - On the influence of labeling strategies to infer cell population dynamics. PLoS ONE 2017, 12(10):e0185523
  • Carillo-Bustamante P, Nguyen TH, Oestereich L, Günther S, Guedj J, Graw F: Determining Ribavirin's mechanism of action against Lassa virus infection. Sci Rep. 2017, 7(1):11693.

2016

  • Graw F, Perelson AS: Modeling viral spread. Annu Rev Virol. 2016 3:555-72.
  • Dahari H, Canini L, Graw F, Uprichard SL, Araujo ES, Penaranda G, Coquet E, Chiche L, Riso A, Renou C, Bourliere M, Cotler SJ, Halfon P: HCV kinetic and modeling analyses indicate similar time to cure among sofosbuvir combination regimens with daclatasvir, simeprevir or ledipasvir. J Hepatol. 2016, 64:1232-9 doi:10.1016/j.hep.2016.02.022.
  • Kumberger P, Frey F, Schwarz US, Graw F: Multiscale modeling of virus replication and spread. FEBS Letters 2016, 590:1972-86.

2015

  • Madelain V, Oestereich L, Graw F, Nguyen TH, de Lamballerie X, Mentre F, Günther S, Guedj J: Ebola virus dynamics in mice treated with favipiravir. Antiviral Res. 2015, doi:10.1016/j.antiviral.2014.08.015.
  • Garcia V, Richter K, Graw F, Oxenius A, Regoes RR: Estimating the in vivo killing efficacy of cytotoxic T lymphocytes across different peptide-MHC complex densities. PLoS Computational Biology 2015, 11(5):e1004178.
  • Graw F, Martin DN, Perelson AS, Uprichard SL*, Dahari H*: Quantification of Hepatitis C virus cell-to-cell spread using a stochastic modeling approach. Journal of Virology 2015, 89:6551-61 (*these authors contributed equally)
  • Johnson S*, Bergthaler A*, Graw F*, Flatz L, Bonilla WV, Siegrist CA, Lambert PH, Regoes RR#, Pinschewer DD#: Protective efficacy of individual CD8+ T cell specificities in chronic viral infection. Journal of Immunology 2015, 194:1755-62. (*,# these authors contributed equally)

2014

  • Graw F, Balagopal A, Kandathil AJ, Ray SC, Thomas DL, Ribeiro RM, Perelson AS: Inferring viral dynamics in chronically HCV infected patients from the spatial distribution of infected hepatocytes. PLoS Computational Biology 2014, 10(11):e1003934.
  • Graw F, Regoes RR: Predicting the impact of CD8+ T cell polyfunctionality on HIV disease progression. J Virol 2014, 88(17): 10134-45
  • Bastidas S, Graw F, Smith MZ, Kuster H, Günthard HF, Oxenius A: CD8+ T cells are activated in an antigen-independent manner in HIV infected individuals. Journal of Immunology 2014, 192:1732-44

2013

  • Seich al-Basatena NK, Chatzimichalis K, Graw F, Frost SDW, Regoes RR, Asquith B: Can non-lytic CD8+ T cells drive HIV-1 escape?PLoS Pathogens 2013, 9(11):e1003656
  • Kandathil AJ, Graw F, Quinn J, Hwang HS, Torbenson M, Perelson AS, Ray SC, Thomas DL, Ribeiro RM, Balagopal A: Use of lase capture microdissection to map HCV-positive hepatocytes in human liver. Gastroenterology 2013, 145:1404-1413

2012

  • Graw F, Weber KS, Allen PM, Perelson AS: Dynamics of CD4+ T cell responses against Listeria monocytogenes. Journal of Immunology 2012, 189:5250-5256
  • Graw F, Leitner T, Ribeiro RM: Agent-based and phylogenetic analyses reveal how HIV-1 moves between risk groups: Injecting drug users sustain the heterosexual epidemic in Latvia. Epidemics 2012, 4(2):104-116
  • Graw F, Regoes RR: Influence of the fibroblastic reticular network on cell-cell interactions in lymphoid organs. PLoS Computational Biology 2012, 8(3):e1002436

2011

  • Liu P, Overman RG, Yates NL, Alam SM, Vandergrift N, Chen Y, Graw F, Freel SA, Kappes JC, Ochsenbauer C, Montefiori DC, Gao F, Perelson AS, Cohen MS, Haynes BF, Tomaras GD: Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute and chronic HIV-1 infection. Journal of Virology 2011, 85(21):11196-11207
  • Haas A, Zimmermann K, Graw F, Slack E, Rusert P, Ledergerber B, Bossart W, Weber R, Thurnheer MC, Battegay M, Hirschel B, Vernazza P, Patuto N, Macpherson AJ, Gunthard HF, Oxenius A, the Swiss HIV Cohort Study: Systemic antibody responses to gut commensal bacterai during chronic HIV-1 infection. Gut 2011, 60(11):1506-1519
  • Graw F, Richter K, Oxenius A, Regoes RR: Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection. Proceedings of the Royal Society - B 2011, 278(1723):3395-3402

2010

  • Graw F*, Magnus C*, Regoes RR: Theoretical analysis of the evolution of immune memory. BMC Evolutionary Biology 2010, 10:380 (* these authors contributed equally)
  • Haas A, Rehr M, Graw F, Rusert P, Bossart W, Kuster H, Trkola A, Gunthard HF, Oxenius A: HIV-1 replication activates CD4+ T cells with specificities for persistent herpes virus. EMBO Molecular Medicine 2010, 2(6):231-244

2009

  • Graw F, Regoes RR: Investigating CTL mediated killing with a 3D cellular automaton. PLoS Computational Biology 2009, 5(8):e1000466
  • Graw F, Gerds  TA, Schumacher M: On pseudo-values for regression analysis in competing risks models. Lifetime Data Analysis 2009, 15(2):241-255

2007

  • Yates A, Graw F, Barber DL, Ahmed R, Regoes RR, Antia R: Revisiting estimates of CTL killing in vivo. PLoS ONE 2007, 2(12)

 

Books and contributed book chapters

  • Graw F, Matthäus F, Pahle J (Editors): Modeling Cellular Systems, Contributions in Mathematical and Computational Sciences 11, 2017, Springer
  • Graw F, Perelson AS: Spatial aspects of HIV infection, contributed book chapter, Mathematical Methods and Models in Biomedicine, 2012, Springer
Contact: E-Mail (Last update: 07/02/2023)