University of Heidelberg
BIOQUANT

Arne Schoch

Im Neuenheimer Feld 267

69120 Heidelberg, Germany

email: arne.schoch(at)bioquant.uni-heidelberg.de

phone: +49 (0)6221-54 51353

room: 541

Projects: Decoding of calcium signals

 

Calcium ions act as second messengers in many biological systems. In cells a diverse set of agonists can induce a signaling cascade that utilizes calcium for its information transfer. Similarly, calcium operates on numerous targets including a large number of proteins to ultimately regulate different cellular responses. The oscillation dynamics of cytosolic calcium can vary dependent on the cell and agonist type. Oscillation frequency, duration, amplitude and the general form of the oscillation (for example spiking or bursting behaviors) are all variable factors. It is assumed that this diversity of the calcium oscillation dynamics directs the selective targeting of downstream proteins.

My PhD objective is to identify relevant factors in the calcium signal that cause a directed response to a downstream target. Secondly, we apply the information-theoretic measure of transfer entropy to detect nonlinear dependencies between time series. Since the estimation of transfer entropy goes along with critical drawbacks due to parameter-dependent biases, a methodological focus is set on obtaining validated results and propose a best-practice workflow for transfer entropy estimations.

Contact: E-Mail (Last update: 17/12/2016)