Single-Cell Open Lab
Dr. Jan-Philipp Mallm
We provide specialized support for diverse single-cell sequencing methods, including spatial omics, tailored specifically for cancer research. Our services encompass project design, training, and implementation of techniques, prioritizing the exploration of tumor heterogeneity and resistance to chemotherapy. Through advanced automation and chemistry, we deliver comprehensive workflows from tissue to sequencing libraries.
Research Strategy
The Single-cell Open Lab provides technical infrastructure and expertise for single-cell sequencing workflows which includes droplet and plate-based techniques as well as spatial omics. We offer support in project design, grant proposal, and proof-of-concept experiments, training of users, and implementation of new techniques tailored to cancer research. Our aim is to provide complete workflows from tissues to read-to-sequence libraries. Central chemistry and optimized tissue preparations are available alongside automated library preparation frameworks. Scientifically, we focus on tumor heterogeneity in the context of resistance toward chemotherapy.
The single-cell field is fast evolving, with improved and new methods being published weekly. We will mainly focus on two aspects: Multi-omics readouts, especially in connection with spatial information, and Moving single-cell technology to the clinic. In both cases, we will work closely with research groups in BioQuant and institutes across the campus within the SciNetID research network, e.g., the National Center for Tumor Diseases (NCT) and the Hopp Children’s Cancer Center Heidelberg (KITZ).
Dr. Jan-Philipp Mallm
- +49 (0)6221 54-51322
- jan-philipp.mallm@bioquant.uni-heidelberg.de
- Room 423-425
- Find out more information here
Selected Publications
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Mathias Heikenwalder, et al.
Nature volume 592, pages 450-456 (2021)
Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab & Karsten Rippe.
Nature Communications volume 12, Article number: 6960 (2021)
Tobias Roider, Julian Seufert, Alexey Uvarovskii, Felix Frauhammer, Marie Bordas, Nima Abedpour, Marta Stolarczyk, Jan-Philipp Mallm, Sophie A Herbst, Peter-Martin Bruch, Hyatt Balke-Want, Michael Hundemer, Karsten Rippe, Benjamin Goeppert, Martina Seiffert, Benedikt Brors, Gunhild Mechtersheimer, Thorsten Zenz, Martin Peifer, Björn Chapuy, Matthias Schlesner, Carsten Müller-Tidow, Stefan Fröhling, Wolfgang Huber, Simon Anders, Sascha Dietrich
Nat Cell Biol. 2020 Jul;22(7):896-906.