Research Groups hosted in-house
Bischofs Lab: Complex Adaptive Traits (CAT)
Dr. Ilka Bischofs-Pfeifer
Our goal is to understand, to control and to engineer CATs using tools from molecular biology, microscopy and mathematical modelling.
Chlanda Lab: Membrane Biology of Viral Infection
Dr. Petr Chlanda
We are studying how viruses interact with cellular membranes and lipids during infection.
Erfle Lab: High-content Analysis of the Cell (HiCell)
Dr. Holger Erfle
The main focus is the design, development and application of novel technologies for high-content screening and analysis.
Grabe Lab: Tissue Imaging and Analysis (TIGA) Center
Prof. Niels Grabe
We are dedicated to the quantitative analysis and modeling of tissues. A strong emphasis is placed on clinically relevant research projects.
Graw Lab: Modelling Infection and Immunity
Dr. Frederik Graw
We investigate infection and immune processes within a host by combining mathematical models and experimental data.
Grimm Lab: Virus-Host Interactions
Prof. Dirk Grimm
We work on gene therapy with non-pathogenic Adeno-associated viruses (AAV) - the most promising and most versatile viral vector for therapeutic gene transfer - which we engineer using a large portfolio of technologies and targeting a variety of diseases.
Biomedical Genomics Group - Health Data Science Unit
Dr. Carl Herrmann
We are working on understanding gene (de)regulation in disease and develop novel methods to integrate large scale genomics datasets, using statistical and machine-learning approaches. We focus in particular on epigenomics data and single-cell approaches.
Modeling of Biological Processes
Prof. Ursula Kummer
We develop methods for the simulation, modelling and analysis of biochemical networks and apply these methods to tackle specific biochemical questions.
Single-cell Open Lab (scOpenLab)
Dr. Jan-Philipp Mallm
We focus on providing automated, high-throughput and multi-omic readouts tailored to cancer research.
Molnár-Gabor Group
Dr. jur. Fruzsina Molnár-Gabor
Niopek Lab: Synthetic Biology
Dr. Dominik Niopek
How can we precisely perturb and control molecular processes in living eukaryotic cells? Our lab approaches this question from a synthetic biology and protein engineering perspective. We juxtapose various methods, namely optogenetics, CRISPR, viral vectors and computation and develop molecular tools to study genome regulation and direct cell function.
Pahle Lab: Biological Information Processing
Dr. Jürgen Pahle
We analyse how living systems take up, process, store and transfer information.
Chromatin Networks
Prof. Karsten Rippe
We combine molecular/cell biology and physics to develop quantitative descriptions that relate the dynamic organization of the (epi)genome with gene expression programs and functional cell states.
Biomedical Computer Vision Group
PD Dr. Karl Rohr
We develop methods and algorithms for computer-based analysis of biological and medical images, in particular, cell microscopy images and medical tomographic images.
Russell Group: Protein Evolution
Prof. Rob Russell
We are interested in all aspects of protein structure, function and evolution. We mostly focus on studies of molecular interactions: protein-protein, protein-peptide, protein-chemical, etc.
Saez-Rodriguez Group: Systems Biomedicine
Prof. Julio Saez-Rodriguez
We study the deregulation of signaling networks to develop novel therapeutics for cancer, autoimmune and fibrotic diseases by integrating multi-omics data and biological knowledge into mathematical models.
Sahle Group: Methods in Computational Systems Biology
Dr. Sven Sahle
We develop computational methods for modeling and analyzing biochemical reaction networks, using different mathematical frameworks like ODEs, PDEs or stochastic processes. As a service for the community we also develop and provide software for general use in systems biology.
Schröder Group: Cryo-Electron Microscopy
Prof. Rasmus Schröder
We cooperate with various Heidelberg groups within the CryoEMNetwork, including research projects in the field of single particle analysis and electron cryo tomography on protein suspensions and cryosections of cellular samples. Our own biomedical focus is on the actin-myosin macromolecular motor system.
Research Groups with projects in-house
Boutros Lab: Signaling Networks / ERC DECODE
Prof. Michael Boutros
We use genetic and genomic approaches to study cellular signaling networks, with a particular focus on Wnt and Wnt-interacting pathway.
Halama Lab: Translational Immunotherapy
PD Dr. Niels Halama
Our group is focusing on immunotherapy of solid tumor. The main interest is in tissue processing workflows and technologies using whole slide image processing/quantification coupled with multiplex protein quantification to address basic scientific questions. These workflows and technologies are being applied in translational projects with implementation in clinical trials.
Health Data Science Unit
Prof. Roland Eils
We are working on novel, interoperable solutions in medical informatics with the aim to make medical patient data accessible for clinical research and education which will, in turn, improve patient care.
Heilemann Lab: Single Molecule Biophysics
Prof. Mike Heilemann
We study the structural organization of biomolecules in cells applying novel microscopic techniques that provide single-molecule sensitivity and a spatial resolution below the diffraction limit.
Huber Group / ERC DECODE
Dr. Wolfgang Huber
Systems Biology of Signal Transduction
Prof. Ursula Klingmüller
Our goal is to gain insights into molecular mechanisms that regulate cellular decisions and to address their impact on behavior at the tissue- and organ-level.
Kräusslich Lab: Retroviral and Influenza Virus (IAV) Biology
Prof. Hans-Georg Kräusslich
Lohmann Lab / ERC DECODE
Prof. Jan Lohmann
Applied Analysis and Modelling in Biosciences
Prof. Anna Marciniak-Czochra
The group is focused on multi-scale mathematical modelling and analysis of the dynamics of structure formation and self-organisation in cell systems.
Schwarz Group: Physics of Complex Biosystems
Prof. Ulrich Schwarz
In our work, we aim at developing a systems level understanding of cell mechanics and adhesion.
Molecular Mechanisms of Intracellular Trafficking
Prof. Vytautė Starkuvienė-Erfle
Our aim is to analyse how intracellular trafficking adapts to extracellular signals. The projects are running at Vilnius University, Lithuania and at Heidelberg University in collaboration with Erfle Lab, BioQuant.