12.00 PM: Registration
01.00 PM: 15 Years BioQuant Scientific Symposium
05.00 PM: Jubilee Party

Find more information on the dedicated 15 years of BioQuant page or register here

hosted by Ilka Bischofs

Spatial organization is a defining characteristic of all living organisms but has been challenging to engineer from the bottom up. By colocalizing specific reactions and separating others, synthetic compartments have the potential to improve the biochemical capabilities of artificial cells and cell-free systems. I will present our recent efforts in engineering spatial organization in biomimetic systems. We use microfluidics to produce porous polymeric cell-mimics containing nucleus-like DNA-hydrogel compartments that are able to express and display proteins. Cell-mimics communicate with each other through diffusive protein and RNA signals, which support the formation of gene expression gradients in cell-mimic communities. Additionally, we have developed lipid sponge droplets as programmable synthetic organelles. Lipid sponge droplets are stable and biocompatible coacervate compartments that self-assemble from a single-chain galactolipid and nonionic detergents. Containing dense membrane networks intersected by nanometric aqueous channels lipid sponge droplets provide reaction spaces for both transmembrane and soluble proteins. We have demonstrated that lipid sponge droplets can be programmed to internally concentrate specific biomolecules, to host and accelerate biochemical transformations, and to rapidly and reversibly sequester and release proteins to control enzymatic reactions. Our results show that a combination of biological and synthetic materials facilitates the engineering of spatial organization in biomimetic systems and will help integrate increasingly complex functions in artificial cells and cell-free systems.

Meeting-ID: 933 4171 7324
Kenncode: 454630

"Systems Biology with an emphasis on Systems Medicine integrates complementary contributions from many different disciplines such as biology, medicine, physics, mathematics, computer science, biochemistry and engineering and currently increasingly advances to translation with applications in medicine. These developments provide important contributions to a transition towards digital health.

Our aim is to bring together an interdisciplinary community and provide ample opportunities for inspiring discussions. The scientific program is structured in sessions on “Single Cells”, “Signal Transduction”, “Metabolism”, “Multiscale Modelling”, “Systems Medicine” and “Digital Pathology” and the internationally recognized invited speakers provide different points of view and a broad overview on ground breaking developments in these areas. For each session, short talk presentations are selected from the contributed abstracts to facilitate the presentation of latest advancements especially by young scientists.

To reflect on the benefits and challenges of translation into medical application, we are organizing a panel discussion on “Ethical aspects of digital health: Quo vadis?”.

Ample opportunity for networking are provided by the conference dinner, Meet the Speakers lunch, Meet the Editors lunch and a poster session. The conference is supported by LiSyM-Cancer, the German network on systems medicine of liver research funded by the ministry of education and research (BMBF)." from SBMC2022.de