Skip to main content




BioQuant Seminar

Unravelling microbial complexity: insights from multi-omics and long-read sequencing approaches

Andre Holzer
Centre for Bioinformatics (ZBI), Saarland University

  4:00 PM     SR41


Microorganisms are ubiquitous and form complex, highly dynamic communities with interconnected metabolic dependencies whenever they inhabit the same environment. Well-known examples of microbial communities include the human gut microbiome, but equally important to life on earth are those in the aquatic environment. Composed of photosynthetic algae, protists and bacteria, the aquatic microcosm is responsible for >50% of global carbon fixation as well as the production of essential primary metabolites such as vitamin B12. 

In this talk, I will provide a comprehensive overview about our recent advancements at the intersection of microbiology, biotechnology, public health, and environmental science.

On the example of vitamin B12, I will elucidate how multi-omics and functional genomics analyses enable us to comprehend, predict, and harness the intricacies of microbial interactions in the aquatic food web. In addition, I will showcase how we are utilising portable Nanopore sequencing to monitor microbial communities in the context of freshwater diagnostics as well as to study connections between environmental signalling and epigenetic changes. Finally, I will conclude with an overview of our ongoing research projects in the realm of Microbial Systems Biology, Real-Time Genomics and Long-read Bioinformatics, offering insights into the scientific trajectory for the upcoming years. 



Dr Andre Holzer studied Molecular Biotechnology at Heidelberg University. After graduating in 2017, he became a Gates Cambridge Scholar and conducted his PhD at the University of Cambridge where his research addressed open questions in Aquatic Microbiology and Algae Biotechnology. During this time, he co-founded the PuntSeq project, a citizen science initative which aims for democratising novel real-time DNA sequencing technology. In 2021, the initiative presented the world’s first open-source, low-cost metagenomics framework to monitor microbial composition of freshwater sources leveraging nanopore sequencing. Andre obtained his PhD from the University of Cambridge in 2021 and continued working as a Postdoctoral Researcher. In 2023 he joined the Center for Bioinformatics (ZBI) at Saarland University where he is currently working as an independent researcher in the fields of Microbial Systems Biology, Real-Time Genomics and Long-Read Bioinformatics.