Molecular Mechanisms of Intracellular Trafficking

Research Strategy

As part of a collaborative effort (Erfle group), we have developed quantitative cell-based assays and high-content imaging techniques, enabling the identification and characterisation of numerous novel trafficking regulators. To achieve an integrative, multi-scale understanding of molecular trafficking mechanisms, we focus on studying the principles of endocytosis in 3D cell cultures. In collaboration with data modeling groups (Kummer and Sahle group), we aim to build predictive models of cargo diffusion, internalization, and endosomal release, enhancing our ability to characterize trafficking processes in disease-relevant contexts and drug action.